FAMICEF

Cefuroxime Axetil

Antiinfective

 
 
 
 
 


Indication

Upper respiratory tract infections: Ear, nose and throat infections such as otitis media, sinusitis, tonsillitis, and pharyngitis.

Lower respiratory tract infection: Acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia.

Skin and soft tissue infections: Furunculosis, pyoderma and impetigo.

Genito-urinary tract infections: Pyelonephritis, urethritis and cystitis.

Multidrug-resistant typhoid fever.

Gonorrhoea: Acute uncomplicated gonococcal urethritis and cervicitis.

Early Lyme Disease and subsequent prevention of late Lyme Disease.


Dosage and Administration

Infection

Dosage

Duration

Adolescents and Adults (13 years and older)

Pharyngitis / tonsillitis

250 mg b.i.d.

10 days

Acute bacterial maxillary sinusitis

250 mg b.i.d.

10 days

Acute bacterial exacerbations of chronic bronchitis

250 or 500 mg b.i.d.

10 days

Secondary bacterial infections of acute bronchitis

250 or 500 mg b.i.d.

5 - 10 days

Uncomplicated skin and skin-structure infections

250 or 500 mg b.i.d.

10 days

Uncomplicated urinary tract infections

125 or 250 mg b.i.d.

7 - 10 days

Uncomplicated gonorrhoea

1,000 mg once

Single dose

Early Lyme Disease

500 mg b.i.d

20 days

Pediatric Patients (who can swallow tablets whole)

Acute otitis media

250 mg b.i.d.

10 days

Acute bacterial maxillary sinusitis

250 mg b.i.d.

10 days

Infection

Dosage (divided b.i.d.)

Maximum Dose

Duration

Pediatric Patients (3 months to 12 years)

Pharyngitis / tonsillitis

20 mg/kg/day

500 mg

10 days

Acute otitis media

30 mg/kg/day

1,000 mg

10 days

Acute bacterial maxillary sinusitis

30 mg/kg/day

1,000 mg

10 days

Impetigo

30 mg/kg/day

1,000 mg

10 days

      

Injection : Adult : 750 mg three times daily by IM / IV injection.

Infants and Children : 30 - 100 mg / kg /day given in 3 or 4 equally divided doses. A dose of 60 mg / kg /day is appropriate for most infections.

Neonate : 30 - 100 mg / kg / day given in 2 or 3 equally divided doses.

Surgical prophylaxis : 1.5 gm by IV injection at induction of anaesthesia. Thereafter, give 750 mg IM / IV every 8 hours when the procedure is prolonged.

Sequential therapy in adults : Pneumonia : 1.5 gm IV injection three times or twice daily for 2 - 3 days, followed by 500 mg twice daily (oral) for 7 - 10 days. Acute exacerbations of chronic bronchitis : 750 mg three times or twice daily (IM / IV injection) for 2 - 3 days, followed by 500 mg twice daily (oral) for 5 - 10 days. (Duration of both parenteral and oral therapy is determined by the severity of the infections and the clinical status of the patient).

Other recommendations : In Gonorrhoea : Adults : 1.5 gm as a single dose (as 2 X 750 mg injections given intramuscularly with different sites, e.g. each buttock). In Meningitis : Adults : 3 gm IV injection three times daily.

Children (above 3 months of age) : 200 - 240 mg / kg /day by IV injection in 3 or 4 divided doses reduced to 100 mg / kg / day after 3 days or on clinical improvement.

Neonates : 100 mg / kg / day by IV injection reduced to 50 mg / kg / day.

In bone and joint infections : Adults : 1.5 gm injection 3 times daily.

Children (above 3 months of age) : 150 mg / kg / day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.


Composition

Famicef® 250 Tablet : Cefuroxime Axetil USP 250 mg.

Famicef® 500 Tablet : Cefuroxime Axetil USP 500 mg.

Famicef® Powder for Suspension : Cefuroxime Axetil USP 125 mg /5 ml.

Famicef® 750 mg IM / IV Injection : Cefuroxime Sodium USP sterile powder equivalent to Cefuroxime 750 mg / vial.

Famicef® 1.5 g IV injection : Cefuroxime Sodium USP sterile powder equivalent to Cefuroxime 1.5 g / vial.

 
 

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