Napro-A Plus (Naproxen & Esomeprazole) is indicated for the treatment of the signs and symptoms of osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to decrease the risk of developing gastric ulcers in patients at risk for developing NSAID-associated gastric ulcers.
Dosage and Administration
The usual recommended dose for Napro-A Plus :
Recommended (and Maximum)
Dose per day
Napro-A Plus 375
Osteoarthritis, Rheumatoid Arthritis,
Ankylosing Spondylitis and Dysmenorrhoea
Napro-A Plus 500
The tablet must be swallowed whole with water but not be split, chewed, crushed or dissolved. Napro-A Plus should be taken at least 30 minutes before meal.
Geriatric use (>65 years)
Patients older than 65 years and frail or debilitated patients are more susceptible to a variety of adverse reactions from NSAIDs. The incidence of these adverse reactions increases with dose and duration of treatment. For such patients, to minimize the potential risk for an adverse event, the lowest effective dose should be used for the shortest possible duration.
Patients with renal impairment
In patients with mild to moderate renal impairment Naproxen / Esomeprazole should be used cautiously and renal function should be monitored closely. This preparation is contraindicated in patients with severe renal impairment or deteriorating renal disease.
Patients with hepatic impairment
In patients with mild to moderate hepatic impairment Naproxen / Esomeprazole should be used cautiously and hepatic function should be monitored closely. This preparation is contraindicated in patients with severe hepatic impairment.
Children (<18 years)
Naproxen-Esomeprazole is not recommended for use in children under 18 years of age.
Napro-A Plus 375 tablet : Naproxen BP 375 mg & Esomeprazole BP 20 mg.
Napro-A Plus 500 tablet : Naproxen BP 500 mg & Esomeprazole BP 20 mg.