Indication
Haemorrhage or risk of haemorrhage in increased fibrinolysis or fibrinogenolysis. Local fibrinolysis may occur in the following conditions: Prostatectomy and bladder surgery, Menorrhagia, Epistaxis, Conisation of the cervix , Management of dental extraction in patients with coagulopathies, Ulcerative colitis, Haematuria, Gastrointestinal haemorrhage, General fibrinolysis as in prostatic and pancreatic cancer; after thoracic and other major surgery; in obstetrical complications such as abruptio placentae and post-partum haemorrhage; in leukaemia and liver diseases and in connection with thrombolytic therapy with streptokinase. Also indicated for hereditary angioneurotic oedema
Dosage and Administration
2 - 3 tablets of 500 mg (15 - 25 mg/Kg), or 5 - 10 ml by slow intravenous injection at a rate of 1mL/minute, two to three times daily.
Prostatectomy: 5 - 10 ml by slow intravenous injection every eight hours (the first injection being given during the operation) for the first three days after surgery; thereafter 1 - 1.5 g orally three to four times daily until macroscopic haematuria is no longer present.
Menorrhagia : 1 g (2 tablets) orally three times daily for up to four days. Maximum dose 4 g daily. Tracid® therapy is initiated when bleeding has become profuse.
Epistaxis : 1.5 g orally three times daily for four to ten days. Tracid® solution for injection may be applied topically to the nasal mucosa of patients suffering from epistaxis. This can be done by soaking a gauze strip in the solution, and then packing the nasal cavity.
Haematuria : 1 - 1.5 g orally 2 - 3 times daily until macroscopic haematuria is no longer present.
Conisation of the Cervix : 1.5 g orally 3 times a day for 12 to 14 days post-operatively.
Dental Surgery in Patients with Coagulopathies : Immediately before surgery, 10 mg per kg body-weight should be given intravenously. After surgery, 25 mg per kg body-weight are given orally three to four times daily for six to eight days.
General Fibrinolysis: 1.0 g (10 ml) by slow intravenous injection three to four times daily.
Hereditary Angioneurotic Oedema : 1 - 1.5 g orally two to three times daily as intermittent or continuous treatment depending on whether the patient has prodromal symptoms or not.
Composition
Tracid 500 Tablet: Each film-coated tablet contains Tranexamic Acid BP 500 mg.
Tracid 650 Tablet: Each film-coated tablet contains Tranexamic Acid 650 mg.
Injection IV/ IM: Each 5ml ampoule contains Tranexamic Acid BP 500 mg.